Cutaneous Angiosarcoma: A Single-Institution Experience
Identifieur interne : 003747 ( Main/Exploration ); précédent : 003746; suivant : 003748Cutaneous Angiosarcoma: A Single-Institution Experience
Auteurs : Matthew C. Perez [États-Unis] ; Tapan A. Padhya [États-Unis] ; Jane L. Messina [États-Unis] ; Ryan S. Jackson [États-Unis] ; Ricardo J. Gonzalez [États-Unis] ; Marilyn M. Bui [États-Unis] ; G. Douglas Letson [États-Unis] ; C. W. Cruse [États-Unis] ; Robert S. Lavey [États-Unis] ; David Cheong [États-Unis] ; Meghan R. Forster [États-Unis] ; William J. Fulp [États-Unis] ; Msvernon K. Sondak [États-Unis] ; Jonathan S. Zager [États-Unis]Source :
- Annals of surgical oncology [ 1068-9265 ] ; 2013.
Abstract
Cutaneous angiosarcoma (CAS) is a rare, aggressive vascular sarcoma with a poor prognosis, historically associated with 5-year overall survival (OS) rates between 10 and 30 %.
This is a single-institution retrospective review of patients treated for CAS from 1999–2011. Demographics, primary tumor characteristics, treatment, and outcomes were analyzed.
A total of 88 patients were identified (median age 70 years and 57 % female). Median tumor size was 3 cm. Median follow-up was 22 months. The 5-year OS and recurrence-free survival (RFS) were 35.2 and 32.3 %, respectively; median was 22.1 months. Also, 36 patients (41 %) received surgery alone, 7 (8 %) received XRT alone, and 41 (47 %) received surgery and XRT. Of the 67 of 88 patients who were disease-free after treatment, 33 (50 %) recurred (median of 12.3 months). Surgery alone had the highest 5-year OS (46.9 %) and RFS (39.9 %) (
In this large series, there appears to be a better overall prognosis than historically reported, especially in Stewart–Treves and CAS on trunk or extremities. While surgery alone was associated with better OS and RFS compared with other treatment modalities, this was not statistically significant. Tumor size was a significant prognostic factor for OS.
Url:
DOI: 10.1245/s10434-013-3083-6
PubMed: 23835652
PubMed Central: 4509495
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Cutaneous angiosarcoma (CAS) is a rare, aggressive vascular sarcoma with a poor prognosis, historically associated with 5-year overall survival (OS) rates between 10 and 30 %.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">This is a single-institution retrospective review of patients treated for CAS from 1999–2011. Demographics, primary tumor characteristics, treatment, and outcomes were analyzed.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">A total of 88 patients were identified (median age 70 years and 57 % female). Median tumor size was 3 cm. Median follow-up was 22 months. The 5-year OS and recurrence-free survival (RFS) were 35.2 and 32.3 %, respectively; median was 22.1 months. Also, 36 patients (41 %) received surgery alone, 7 (8 %) received XRT alone, and 41 (47 %) received surgery and XRT. Of the 67 of 88 patients who were disease-free after treatment, 33 (50 %) recurred (median of 12.3 months). Surgery alone had the highest 5-year OS (46.9 %) and RFS (39.9 %) (<italic>p</italic>
= ns). Four presentation groups were identified: (1) XRT induced, <italic>n</italic>
= 30 (34 %), 26 of 30 occurred in females with a prior breast cancer, (2) sporadic CAS on head and neck (H/N), <italic>n</italic>
= 38, (3) sporadic CAS on trunk/extremities, <italic>n</italic>
= 13, and (4) Stewart–Treves <italic>n</italic>
= 7. Those with trunk/extremity CAS had the highest 5-year OS (64.8 %), with H/N CAS having the worst 5-year OS (21.5 %). On MV analysis, only tumor size <5 cm correlated with improved OS (<italic>p</italic>
= 0.014).</p>
</sec>
<sec id="S4"><title>Discussion</title>
<p id="P4">In this large series, there appears to be a better overall prognosis than historically reported, especially in Stewart–Treves and CAS on trunk or extremities. While surgery alone was associated with better OS and RFS compared with other treatment modalities, this was not statistically significant. Tumor size was a significant prognostic factor for OS.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Floride</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Floride"><name sortKey="Perez, Matthew C" sort="Perez, Matthew C" uniqKey="Perez M" first="Matthew C." last="Perez">Matthew C. Perez</name>
</region>
<name sortKey="Bui, Marilyn M" sort="Bui, Marilyn M" uniqKey="Bui M" first="Marilyn M." last="Bui">Marilyn M. Bui</name>
<name sortKey="Bui, Marilyn M" sort="Bui, Marilyn M" uniqKey="Bui M" first="Marilyn M." last="Bui">Marilyn M. Bui</name>
<name sortKey="Cheong, David" sort="Cheong, David" uniqKey="Cheong D" first="David" last="Cheong">David Cheong</name>
<name sortKey="Cruse, C W" sort="Cruse, C W" uniqKey="Cruse C" first="C. W." last="Cruse">C. W. Cruse</name>
<name sortKey="Forster, Meghan R" sort="Forster, Meghan R" uniqKey="Forster M" first="Meghan R." last="Forster">Meghan R. Forster</name>
<name sortKey="Fulp, William J" sort="Fulp, William J" uniqKey="Fulp W" first="William J." last="Fulp">William J. Fulp</name>
<name sortKey="Gonzalez, Ricardo J" sort="Gonzalez, Ricardo J" uniqKey="Gonzalez R" first="Ricardo J." last="Gonzalez">Ricardo J. Gonzalez</name>
<name sortKey="Gonzalez, Ricardo J" sort="Gonzalez, Ricardo J" uniqKey="Gonzalez R" first="Ricardo J." last="Gonzalez">Ricardo J. Gonzalez</name>
<name sortKey="Jackson, Ryan S" sort="Jackson, Ryan S" uniqKey="Jackson R" first="Ryan S." last="Jackson">Ryan S. Jackson</name>
<name sortKey="Jackson, Ryan S" sort="Jackson, Ryan S" uniqKey="Jackson R" first="Ryan S." last="Jackson">Ryan S. Jackson</name>
<name sortKey="Lavey, Robert S" sort="Lavey, Robert S" uniqKey="Lavey R" first="Robert S." last="Lavey">Robert S. Lavey</name>
<name sortKey="Letson, G Douglas" sort="Letson, G Douglas" uniqKey="Letson G" first="G. Douglas" last="Letson">G. Douglas Letson</name>
<name sortKey="Messina, Jane L" sort="Messina, Jane L" uniqKey="Messina J" first="Jane L." last="Messina">Jane L. Messina</name>
<name sortKey="Messina, Jane L" sort="Messina, Jane L" uniqKey="Messina J" first="Jane L." last="Messina">Jane L. Messina</name>
<name sortKey="Padhya, Tapan A" sort="Padhya, Tapan A" uniqKey="Padhya T" first="Tapan A." last="Padhya">Tapan A. Padhya</name>
<name sortKey="Sondak, Msvernon K" sort="Sondak, Msvernon K" uniqKey="Sondak M" first="Msvernon K." last="Sondak">Msvernon K. Sondak</name>
<name sortKey="Sondak, Msvernon K" sort="Sondak, Msvernon K" uniqKey="Sondak M" first="Msvernon K." last="Sondak">Msvernon K. Sondak</name>
<name sortKey="Zager, Jonathan S" sort="Zager, Jonathan S" uniqKey="Zager J" first="Jonathan S." last="Zager">Jonathan S. Zager</name>
<name sortKey="Zager, Jonathan S" sort="Zager, Jonathan S" uniqKey="Zager J" first="Jonathan S." last="Zager">Jonathan S. Zager</name>
</country>
</tree>
</affiliations>
</record>
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